Unsigned players in the first 10 rounds, and their negotiation status as of Wednesday evening:
| Rd | Pick | Team | Player, Pos. | Status |
| 1 | 2 | Pirates | Pedro Alvarez, 3b | Seeking over-slot deal |
| 1 | 3 | Royals | Eric Hosmer, 1b | Seeking over-slot deal |
| 1 | 4 | Orioles | Brian Matusz, lhp | Seeking over-slot deal |
| 1 | 5 | Giants | Buster Posey, c | Seeking over-slot deal |
| 1 | 7 | Reds | Yonder Alonso, 1b | Seeking over-slot deal |
| 1 | 9 | Nationals | Aaron Crow, rhp | Seeking over-slot deal |
| 1 | 11 | Rangers | Justin Smoak, 1b | Seeking over-slot bonus |
| 1 | 20 | Mariners | Joshua Fields, rhp | Seeking over-slot bonus |
| 1 | 23 | Padres | Allan Dykstra, 1b | Has medical issues (hip) |
| 1 | 28 | Yankees | Gerrit Cole, rhp | Seeking over-slot bonus |
| 1s | 44 | Yankees | Jeremy Bleich, lhp | May get seven-figure bonus |
| 2 | 47 | Rays | Kyle Lobstein, lhp | May get seven-figure bonus |
| 2 | 48 | Pirates | Tanner Scheppers, rhp | Has medical issues (shoulder) |
| 2 | 57 | Rangers | Robbie Ross, lhp | Seeking over-slot bonus |
| 2 | 69 | Padres | James Darnell, 3b | Reportedly close to signing |
| 2 | 75 | Yankees | Scott Bittle, rhp | Has medical issues (shoulder) |
| 2 | 76 | Indians | Trey Haley, rhp | May get seven-figure bonus |
| 3 | 88 | Astros | Chase Davidson, 1b | Expected to attend Georgia |
| 3s | 112 | Angels | Zach Cone, of | Expected to attend Georgia |
| 4 | 115 | Royals | Tim Melville, rhp | May get seven-figure bonus |
| 4 | 135 | Padres | Jason Kipnis, of | Expected to return to Arizona State |
| 4 | 142 | Red Sox | Pete Hissey, of | May get seven-figure bonus |
| 5 | 167 | Rockies | Chris Dominguez, 3b | Expected to return to Louisville |
| 5 | 169 | Angels | Khiry Cooper, of | Expected to attend Nebraska (football) |
| 5 | 171 | Indians | Zach Putnam, rhp | May get over-slot bonus |
| 5 | 172 | Red Sox | Ryan Westmoreland, of | May get seven-figure bonus |
| 6 | 174 | Pirates | Robbie Grossman, of | May get over-slot bonus |
| 6 | 186 | Twins | B.J. Hermsen, rhp | Reportedly close to signing |
| 7 | 205 | Royals | Jason Esposito, 3b | Expected to attend Vanderbilt |
| 7 | 210 | White Sox | Jordan Danks, of | May get over-slot bonus |
| 7 | 214 | Athletics | Brett Hunter, rhp | Has medical issues (elbow) |
| 7 | 226 | Phillies | Johnny Coy, 3b | Expected to attend Arizona State (basketball) |
| 9 | 282 | Mariners | Billy Morrison, rhp | Expected to return to Western Michigan |
| 9 | 285 | Padres | Kyle Thebeau, rhp | Expected to return to Texas A&M |
| 10 | 294 | Pirates | Drew Gagnon, rhp | May get over-slot bonus |
| 10 | 296 | Orioles | Chris Herrmann, 3b | Expected to attend Miami |
| 10 | 297 | Giants | Ryan O'Sullivan, rhp | May get over-slot bonus |
| 10 | 298 | Marlins | Trevor Holder, rhp | Expected to return to Georgia |
| 10 | 303 | Rangers | Kevin Castner, rhp | Expected to return to Cal Poly |
| 10 | 307 | Dodgers | Chris Joyce, lhp | Expected to attend UC Santa Barbara |
| 10 | 310 | Braves | J.J. Hoover, rhp | Pitching in Cape Cod League playoffs |
| 10 | 311 | Cubs | Alex Wilson, rhp | Expected to return to Texas A&M |
| 10 | 312 | Mariners | Nate Newman, rhp | Expected to return to Pepperdine |
| 10 | 318 | D'backs | Danny Hultzen, lhp | Expected to attend Virginia |